Multi-site modeling of land surface-atmosphere exchanges at the extent of an agricultural Mediterranean region Carlo Montes Mediterranean regions are characterized by low rainfall amounts and a strong sea- sonality in its distribution. In these regions, evapotranspiration (ET) corresponds to the main component of the hydrological cycle, so that quantifying land surface-atmosphere exchanges is a crucial issue in order to assess climate-vegetation feedbacks or water consumption by plants. Re- cent advances in terms of modeling and remote sensing, mainly at the sub-regional level for full cover canopies, allow foreseeing the regional extent for complex surfaces such as sparse vegetation and row crops. This work proposes a modeling approach of soil-vegetation-atmosphere transfers that can be used at the extent of an agricultural region, combined with a parameter optimization procedure and optical and infrared remote sensing methods. Initially, a 1-D model with regional focus was developed to simulate the energy and water balance of a row crop (vineyard). The model was validated using ground-based data in southern France, and multi-criteria methods were used in order to perform a sensitivity analysis and model calibration. Secondly, remote sensing data were used in order to estimate watershed ET by using a contextual approach with Landsat and ASTER imagery. Finally, satellite estimates of ET and soil moisture measurements were used jointly in order to calibrate the model and to obtain multi-site simulations of the water balance on a set of points in the study area.